The phosphate salt of codeine takes place as white, needle-shaped crystals or white crystalline powder. Codeine phosphate is freely soluble in water and somewhat soluble in Liquor. The molecular bodyweight is 406.37. Its molecular formula is C18H21NO3•H3PO4 • ½ H2O, and it's the following chemical framework.
The next laboratory assessments may be impacted in sufferers who will be acquiring therapy with promethazine hydrochloride.
are pregnant or program to become Expecting. Promethazine Hydrochloride and Codeine Phosphate Oral Resolution can harm your unborn infant. See “What's the most important facts I should really learn about Promethazine Hydrochloride and Codeine Phosphate Oral Answer?” are breastfeeding or decide to breastfeed. Codeine passes into your breast milk and can cause major Unintended effects inside your newborn including greater sleepiness, breathing problems (respiratory despair), and death. It's not necessarily regarded if promethazine can pass into your breast milk.
The following severe adverse reactions are explained, or described in increased detail, in other sections:
The combination of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric people under six yrs of age. Concomitant administration of promethazine solutions with other respiratory depressants has an association with respiratory depression, and at times Dying, in pediatric patients.
Neuroleptic malignant syndrome (NMS) which can cause Dying. Tell you Health care service provider straight away When you've got any of the following indications of NMS:
This can occur even if you acquire Promethazine Hydrochloride and Codeine Phosphate Oral Alternative exactly as prescribed by your healthcare provider. Your risk of dependancy, abuse, and misuse is increased in the event you or perhaps a family member features a background of drug or Alcoholic beverages abuse or dependancy, or psychological health issues.
Certain experiments to test the action on the drug on parturition, lactation, and enhancement from the animal neonate were not performed, but a general preliminary research in rats indicated no effect on these parameters.
Acute or extreme bronchial bronchial asthma in an unmonitored location or in absence of resuscitative tools. (four)
Prevention and Charge of nausea and vomiting connected to sure varieties of anesthesia and surgical procedure.
The mix of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric clients below 6 decades of age, for the reason that The mixture may well trigger lethal respiratory melancholy On this age population. It's important that promethazine hydrochloride and codeine phosphate syrup is measured with the correct measuring unit (see Safety measures-Information and facts for Clients).
The opioid antagonists, naloxone and nalmefene, are certain antidotes for respiratory depression resulting from opioid overdose. For clinically considerable respiratory or circulatory melancholy secondary to codeine overdose, administer an opioid antagonist. An antagonist really should not be administered while in the absence of clinically significant respiratory despair. Because the duration of opioid reversal is predicted to be below the duration of action of codeine in Promethazine HCl and Codeine Phosphate Oral Remedy, cautiously keep track of the patient until spontaneous respiration is reliably reestablished.
Lactation At the very least one Demise was noted inside of a nursing infant who was subjected to higher amounts of morphine in breast milk because check here the mom was an extremely-speedy metabolizer of codeine.
Sedation in both of those young children and adults, and reduction of apprehension and production of mild rest from which the affected person is usually quickly aroused.